The Benefits of Non-Curcuminoids

Who knows the name of the third Hemsworth brother? Most of us would have to do a google search for the answer...In the same way, we’ve all heard about the benefits of curcuminoids from Curcuma longa but what about the other active compounds in turmeric? Their therapeutic effects are just as powerful, adding weight to a more ‘whole herb’ approach.

An interesting study on patients aged 16-60 years of age with gastric or duodenal ulcers, examined participants for endoscopical change in the endothelial mucosa after taking two 300mg capsules containing multiple turmeric compounds, five times daily.1

Patients underwent endoscopy at 4, 8 and 12 weeks. The results after 4 weeks of treatment showed that ulcers were absent in 48% of cases, after 8 weeks of treatment ulcers had resolved in 72% of cases, while 76% of people did not have ulcers after 12 weeks of treatment.1

Those participants without ulcers but who had gastrointestinal (GIT) symptoms including gastritis, dyspepsia, epigastric pain, vomiting and melena received the same dose for 4 weeks. Abdominal pain and discomfort subsided in the first and second week.1

A review of the essential medicinal chemistry of Curcuma longa reveals that the benefits are very much the sum of its parts. While the curcuminoids curcumin, demethoxycurcumin and bisdemethoxycurcumin certainly have essential actions, the volatile oils, fibre, minerals, protein, fat and carbohydrates contain compounds with high therapeutic value.2

These compounds include tumerones which can increase the transport of curcumin into GIT epithelial cells; curdione that has an inhibitory effect on prostaglandin E2 (PGE2); biscurone is reported to downregulate tumor necrosis factor-alpha (TNF-α); Ukonan A, B, C & D exhibit immunomodulatory effects; β-Elemene can inhibit tumor growth in GIT cells; and Calebin A which may induce apoptosis in human gastric and colon cancer cells.3,4,5,6,7


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References

Prucksunand C, Indrasukhsri B, Leethochawalit M, Hungspreugs K. Phase II clinical trial on effect of the long turmeric ( Curcuma longa Linn ) on healing of peptic ulcer . PubMed Commons. Southeast Asian J Trop Med Public Heal. 2001;32(1):208-215.
Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The Essential Medicinal Chemistry of Curcumin. J Med Chem. 2017;60(5):1620-1637. doi:10.1021/acs.jmedchem.6b00975
Yue GGL, Cheng S-W, Yu H, et al. The Role of Turmerones on Curcumin Transportation and P-Glycoprotein Activities in Intestinal Caco-2 Cells. J Med Food. 2012;15(3):242-252. doi:10.1089/jmf.2011.1845
Oh O-J, Min H-Y, Lee SK. Inhibition of inducible prostaglandin E2 production and cyclooxy-genase-2 expression by curdione fromCurcuma zedoaria. Arch Pharm Res. 2007;30(10):1236-1239. doi:10.1007/bf02980264
Kawasaki K, Muroyama K, Yamamoto N, Murosaki S. A hot water extract of Curcuma longa inhibits adhesion molecule protein expression and monocyte adhesion to TNF-a-stimulated human endothelial cells. Biosci Biotechnol Biochem. 2015;79(10):1654-1659. doi:10.1080/09168451.2015.1039480
Pan MH, Wu JC, Ho CT, Badmaev V. Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function. J Complement Integr Med. 2017;14(3):4-7. doi:10.1515/jcim-2015-0107
Nair A, Amalraj A, Jacob J, Kunnumakkara AB, Gopi S. Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations. Biomolecules. 2019;9(1):13. doi:10.3390/biom9010013

https://www.bioconcepts.com.au/eresources/turmeric-as-nature-intended?




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